Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.75 |
| ▸ | HTT | P42858 | 4/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.75 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | MEN1 | O00255 | 5/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2439945 | 1.00 | MAPT (0.75) | MAPTALDH1A1HTTL3MBTL1CYP3A4 | |
| Azobenzene SCHEMBL28239152 | 0.96 | MAPT (0.75) | MAPTALDH1A1HTTL3MBTL1CYP3A4 | |
| SCHEMBL61806 | 0.87 | ALDH1A1 (0.65) | MAPTALDH1A1HTTL3MBTL1CYP3A4 | |
| SCHEMBL2437660 | 0.87 | ALDH1A1 (0.65) | MAPTALDH1A1HTTL3MBTL1CYP3A4 | |
| SCHEMBL28848194 | 0.87 | ALDH1A1 (1.00) | MAPTALDH1A1HTTL3MBTL1CYP3A4 | |
| SCHEMBL22282997 | 0.87 | ALDH1A1 (1.00) | MAPTALDH1A1HTTL3MBTL1CYP3A4 | |
| SCHEMBL6405773 | 0.87 | ALDH1A1 (1.00) | MAPTALDH1A1HTTL3MBTL1CYP3A4 | |
| SCHEMBL13644737 | 0.87 | ALDH1A1 (1.00) | MAPTALDH1A1HTTL3MBTL1CYP3A4 | |
| SCHEMBL15371 | 0.87 | ALDH1A1 (1.00) | MAPTALDH1A1HTTL3MBTL1CYP3A4 | |
| SCHEMBL31555953 | 0.85 | ALDH1A1 (0.62) | MAPTALDH1A1HTTL3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8974768-B2 | Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates | MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN (DE) | 2015-03-10 | — | — | US | claimed |
| US-20130078186-A1 | AZO COMPOUNDS REDUCING FORMATION AND TOXICITY OF AMYLOID BETA AGGREGATION INTERMEDIATES | MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN (DE) | 2013-03-28 | — | — | US | claimed |
| EP-2549999-A1 | AZO COMPOUNDS REDUCING FORMATION AND TOXICITY OF AMYLOID BETA AGGREGATION INTERMEDIATES | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2013-01-30 | — | — | EP | claimed |
| WO-2011117305-A1 | AZO COMPOUNDS REDUCING FORMATION AND TOXICITY OF AMYLOID BETA AGGREGATION INTERMEDIATES | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2011-09-29 | — | — | WO | claimed |
| US-8974768-B2 | Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates | MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN (DE) | 2015-03-10 | — | — | US | disclosed |
| US-20130078186-A1 | AZO COMPOUNDS REDUCING FORMATION AND TOXICITY OF AMYLOID BETA AGGREGATION INTERMEDIATES | MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN (DE) | 2013-03-28 | — | — | US | disclosed |
| EP-2368558-A1 | Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates | Mdc Max-Delbrück-Centrum Für Molekulare Medizin Berlin - Buch (DE) | 2011-09-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130078186-A1 | AZO COMPOUNDS REDUCING FORMATION AND TOXICITY OF AMYLOID BETA AGGREGATION INTERMEDIATES | APP, TTR, CRYAB | MAPT 7/4885ALDH1A1 2067/4885HTT 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.