Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.46 |
| ▸ | LCK | P06239 | 7/20 | 0.46 |
| ▸ | TEK | Q02763 | 6/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | RAF1 | P04049 | 6/20 | 0.36 |
| ▸ | CSF1R | P07333 | 5/20 | 0.36 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.36 |
| ▸ | ARAF | P10398 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24399619 | 0.74 | KDR (0.46) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL30400458 | 0.72 | BACE2 (0.39) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL25374814 | 0.72 | BACE2 (0.39) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL24399737 | 0.70 | KDR (0.40) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL30402491 | 0.70 | KDR (0.40) | BRAFLCKTEKKDRRAF1 | |
| SCHEMBL24399759 | 0.69 | BRAF (0.50) | BRAFLCKTEKKDRMAPK14 | |
| SCHEMBL2517832 | 0.69 | BRAF (0.77) | BRAFLCKTEKKDRMAPK14 | |
| SCHEMBL25376024 | 0.68 | PDGFRB (0.39) | BRAFLCKTEKKDRALDH1A1 | |
| SCHEMBL2515737 | 0.67 | BRAF (0.80) | BRAFLCKTEKKDRMAPK14 | |
| SCHEMBL30401854 | 0.66 | GPR119 (0.43) | BRAFLCKTEKKDRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4238967-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022089219-A1 | ARYLAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-05-05 | — | — | WO | disclosed |