Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.52 |
| ▸ | JAK1 | P23458 | 7/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22584067 | 0.79 | TYRO3 (0.47) | JAK2JAK1TYRO3 | |
| SCHEMBL15399202 | 0.78 | JAK2 (0.63) | JAK2JAK1 | |
| Trifluoroacetic Acid SCHEMBL101490 | 0.73 | TYRO3 (0.47) | JAK2JAK1TYRO3 | |
| Trifluoroacetic Acid SCHEMBL16673518 | 0.72 | JAK2 (0.50) | JAK2JAK1 | |
| Trifluoroacetic Acid SCHEMBL15399201 | 0.71 | JAK2 (0.66) | JAK2JAK1 | |
| Trifluoroacetic Acid SCHEMBL98943 | 0.71 | TYRO3 (0.55) | JAK2JAK1TYRO3AXL | |
| Trifluoroacetic Acid SCHEMBL20512407 | 0.71 | TYRO3 (0.55) | JAK2JAK1TYRO3AXL | |
| Trifluoroacetic Acid SCHEMBL29541025 | 0.71 | TYRO3 (0.55) | JAK2JAK1TYRO3AXL | |
| Trifluoroacetic Acid SCHEMBL100175 | 0.71 | TYRO3 (0.55) | JAK2JAK1TYRO3AXL | |
| Trifluoroacetic Acid SCHEMBL29540818 | 0.71 | TYRO3 (0.55) | JAK2JAK1TYRO3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966202-B1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-B]PYRIDINES AND PYRROLO[2,3-B]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORP (US) | 2011-09-21 | — | — | EP | disclosed |