Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10154390 | 0.80 | GSK3B (0.37) | MAPTHTTGSK3BGSK3AGRM4 | |
| SCHEMBL12689594 | 0.79 | GRM4 (0.39) | MAPTGSK3BGSK3AGRM4CDC7 | |
| SCHEMBL20111711 | 0.75 | GPR84 (0.46) | MAPTGSK3BPDPK1CDC7ROCK2 | |
| SCHEMBL22388545 | 0.73 | KDM4E (0.39) | MAPTPDPK1UTS2RKDM4EALDH1A1 | |
| SCHEMBL31303192 | 0.73 | GRM4 (0.45) | GRM4GPR84AXL | |
| SCHEMBL1496225 | 0.73 | GRM4 (0.45) | GRM4GPR84AXL | |
| SCHEMBL10154481 | 0.72 | KMT2A (0.38) | MAPTHTTGSK3BGSK3AGRM4 | |
| SCHEMBL10154391 | 0.72 | PDPK1 (0.43) | MAPTHTTGSK3BGSK3AGRM4 | |
| SCHEMBL20427999 | 0.72 | KDM4E (0.35) | TLR8TLR7KDM4ECNR2 | |
| SCHEMBL10126673 | 0.71 | GSK3A (0.39) | GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3179992-B1 | THERAPEUTIC COMBINATIONS OF A BTK INHIBITOR, A PD-1 INHIBITOR AND/OR A PD-L1 INHIBITOR | ACERTA PHARMA BV (NL) | 2022-05-11 | — | — | EP | disclosed |