Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.70 |
| ▸ | F10 | P00742 | 4/20 | 0.68 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24414766 | 0.90 | AR (0.67) | ARF10KMT2AMEN1HPGD | |
| SCHEMBL25788973 | 0.88 | AR (0.59) | ARF10PDK1PDK2PDK3 | |
| SCHEMBL24414748 | 0.83 | AR (1.00) | ARF10KMT2AMEN1HPGD | |
| SCHEMBL6460829 | 0.81 | F10 (0.68) | ARF10KMT2AMEN1ALDH1A1 | |
| SCHEMBL6459985 | 0.81 | F10 (1.00) | ARF10KMT2AMEN1ALDH1A1 | |
| SCHEMBL3426150 | 0.81 | F10 (0.73) | ARF10PRSS12KMT2AMEN1 | |
| SCHEMBL3034870 | 0.78 | AR (0.62) | ARF10KMT2AMEN1HPGD | |
| SCHEMBL2570856 | 0.78 | AR (0.62) | ARF10KMT2AMEN1HPGD | |
| SCHEMBL6454606 | 0.78 | F10 (0.63) | ARF10KMT2AMEN1ALDH1A1 | |
| SCHEMBL2570857 | 0.78 | AR (0.55) | ARF10KMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691960-B2 | 2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-07-04 | — | — | US | disclosed |
| WO-2022096542-A1 | 2-[THIOPHEN-2-YL)FORMAMIDO]-N-(PHENYL)-2-METHYLPROPANAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-05-12 | — | — | WO | disclosed |
| US-20220144796-A1 | 2-[Thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use therof as medicament | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11691960-B2 | 2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament | IDO1, IDO2, INMT | AR 2770/4885F10 4273/4885PRSS12 416/4885 |
| US-20220144796-A1 | 2-[Thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use therof as medicament | IDO1, IDO2, TPH1 | AR 2457/4885F10 3905/4885PRSS12 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.