Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 20/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2443019 | 0.97 | DGAT1 (0.73) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2442624 | 0.92 | DGAT1 (0.68) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2442619 | 0.92 | DGAT1 (0.68) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2440663 | 0.91 | DGAT1 (0.74) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2440665 | 0.91 | DGAT1 (0.74) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2445396 | 0.90 | DGAT1 (0.66) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2445393 | 0.90 | DGAT1 (0.66) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2440648 | 0.89 | DGAT1 (0.73) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2446555 | 0.88 | DGAT1 (0.72) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2446558 | 0.88 | DGAT1 (0.72) | DGAT1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376454-A2 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Schering Corporation (US) | 2011-10-19 | — | — | EP | disclosed |
| US-20110224193-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | MERCK SHARP & DOHME CORP | 2011-09-15 | — | — | US | disclosed |
| US-20110224193-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | MERCK SHARP & DOHME CORP | 2011-09-15 | — | — | US | disclosed |
| WO-2010059611-A2 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224193-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | DGAT2, DGAT1, LCAT | DGAT1 2/4885CYP3A4 2154/4885CYP2C9 2412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.