Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.35 |
| ▸ | GAPDH | P04406 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LAP3 | P28838 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.33 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28281546 | 0.79 | LMNA (0.44) | LMNATSHRSMN1; SMN2FDPSMAPT | |
| SCHEMBL7568238 | 0.77 | LMNA (0.38) | LMNATSHRSMN1; SMN2OPRM1FDPS | |
| SCHEMBL26624434 | 0.75 | LCK (0.50) | MAPTGPR84FFAR1LCKPPARD | |
| SCHEMBL11024665 | 0.75 | LCK (0.50) | MAPTGPR84FFAR1LCKPPARD | |
| SCHEMBL11659422 | 0.75 | LCK (0.50) | MAPTGPR84FFAR1LCKPPARD | |
| SCHEMBL27513963 | 0.75 | LCK (0.50) | MAPTGPR84FFAR1LCKPPARD | |
| SCHEMBL11661583 | 0.75 | LCK (0.50) | MAPTGPR84FFAR1LCKPPARD | |
| SCHEMBL24735792 | 0.74 | SPHK1 (0.41) | LMNATSHRSMN1; SMN2OPRM1FDPS | |
| SCHEMBL6577529 | 0.74 | LCK (0.48) | TSHRSMN1; SMN2MAPTGPR84FFAR1 | |
| SCHEMBL28742173 | 0.74 | LCK (0.48) | TSHRSMN1; SMN2MAPTGPR84FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678297-A2 | CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN | The U.S.A. as represented by the Secretary, Department of Health and Human Services (US) | 2014-01-01 | — | — | EP | disclosed |
| EP-2539305-A2 | CHRYSOPHAENTIN ANTIMICROBIAL COMPOUNDS THAT INHIBIT FTSZ PROTEIN | The United States of America, as represented by The Secretary, Department of Health and Human Services (US) | 2013-01-02 | — | — | EP | disclosed |
| WO-2012116254-A2 | CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-08-30 | — | — | WO | disclosed |
| WO-2011106630-A2 | CHRYSOPHAENTIN ANTIMICROBIAL COMPOUNDS THAT INHIBIT FTSZ PROTEIN | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-09-01 | — | — | WO | disclosed |