SCHEMBL24423770

SCHEMBL24423770

COc1cc(-c2cc(C(=O)N3CC(C)C(C(=O)O)CC3C)n[nH]2)c(Cl)cn1

nearest known ligand 0.31

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ SCD O00767 1/20 0.31
▸ SCD5 Q86SK9 1/20 0.31
▸ FFAR1 O14842 1/20 0.31
▸ CHRM4 P08173 3/20 0.30
▸ OXTR P30559 1/20 0.30
▸ KDM5A P29375 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24422937 0.92 TDP1 (0.32) CHRM4
SCHEMBL29243465 0.85 FFAR1 (0.31) FFAR1CHRM4OXTR
SCHEMBL29584833 0.85 HCRTR2 (0.34) CHRM4KDM5A
SCHEMBL24424164 0.82 THRB (0.42) —
SCHEMBL24424162 0.82 THRB (0.42) —
SCHEMBL29585433 0.82 THRB (0.42) —
SCHEMBL24424165 0.82 THRB (0.42) —
SCHEMBL24424161 0.82 THRB (0.42) —
SCHEMBL24424163 0.82 THRB (0.42) —
SCHEMBL30629613 0.82 THRB (0.42) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606541-B2 PPARg modulators and methods of use EISAI R&D MANAGEMENT CO., LTD. (JP) 2026-04-21 — — US disclosed
EP-4240736-A1 PPAR GAMMA MODULATORS AND METHODS OF USE Eisai R&D Management Co., Ltd. (JP) 2023-09-13 — — EP disclosed
CN-116635380-A PPARgamma modulators and methods of use 卫材R&D管理有限公司 2023-08-22 — — CN disclosed
US-20230062861-A1 PPARg MODULATORS AND METHODS OF USE EISAI R&D MANAGEMENT CO., LTD. (JP) 2023-03-02 — — US disclosed
US-20230062861-A1 PPARg MODULATORS AND METHODS OF USE EISAI R&D MANAGEMENT CO., LTD. (JP) 2023-03-02 — — US disclosed
WO-2022099144-A1 ΡΡΑRγ MODULATORS AND METHODS OF USE Eisai R&D Mangement Co., Ltd. (JP) 2022-05-12 — — WO disclosed
WO-2022099144-A1 ΡΡΑRγ MODULATORS AND METHODS OF USE Eisai R&D Mangement Co., Ltd. (JP) 2022-05-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230062861-A1 PPARg MODULATORS AND METHODS OF USE PPARG, PPARA, PPARD SCD 210/4885SCD5 241/4885FFAR1 19/4885
US-12606541-B2 PPARg modulators and methods of use PPARG, PPARA, PPARD SCD 683/4885SCD5 880/4885FFAR1 59/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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