SCHEMBL24427482

SCHEMBL24427482

Clc1ccc(-c2ccc3oc4cccc(-c5nc(C6=CCCC=C6)nc(-c6ccccc6)n5)c4c3c2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 1/20 0.35
CSNK2A2 P19784 1/20 0.35
CSNK2B P67870 1/20 0.35
PIM3 Q86V86 1/20 0.35
PIM2 Q9P1W9 1/20 0.35
POLB P06746 2/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34
HPGD P15428 1/20 0.34
KMT2A Q03164 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
ADK P55263 1/20 0.31
PLA2G2A P14555 2/20 0.31
PLA2G4A P47712 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
CASP3 P42574 1/20 0.31
SENP7 Q9BQF6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26899558 0.95 PLA2G2A (0.34) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL19802902 0.94 PLA2G2A (0.34) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL19802695 0.93 PLA2G2A (0.34) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL24314846 0.93 AHR (0.36) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL20962512 0.91 PIM1 (0.35) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL24972690 0.89 PLA2G2A (0.33) PLA2G2APLA2G4APLA2G10
SCHEMBL24315437 0.89 KDM4E (0.34) ALDH1A1MAPTHPGDKMT2APLA2G2A
SCHEMBL20982420 0.88 AHR (0.36) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL24656267 0.88 PLA2G2A (0.34) PIM1CSNK2A2CSNK2BPIM3PIM2
SCHEMBL26321825 0.88 PLA2G2A (0.34) PIM1CSNK2A2CSNK2BPIM3PIM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3596066-B1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2022-05-18 EP disclosed