Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29534370 | 0.83 | POLB (0.41) | LMNAPOLBAAK1CACNA1GCACNA1B | |
| SCHEMBL11927854 | 0.83 | POLB (0.41) | LMNAPOLBAAK1CACNA1GCACNA1B | |
| SCHEMBL31270065 | 0.80 | CACNA1G (0.35) | LMNAPOLBCACNA1GCACNA1BCACNA1C | |
| SCHEMBL13460225 | 0.80 | GABRG2 (0.37) | LMNAPOLBCACNA1GCACNA1BCACNA1C | |
| SCHEMBL23144207 | 0.80 | HRH4 (0.43) | HRH4LMNAPOLBCACNA1BSMN1; SMN2 | |
| SCHEMBL25033104 | 0.80 | CACNA1G (0.35) | LMNAPOLBCACNA1GCACNA1BCACNA1C | |
| SCHEMBL29811800 | 0.80 | HRH4 (0.43) | HRH4LMNAPOLBCACNA1BSMN1; SMN2 | |
| SCHEMBL30836855 | 0.79 | AAK1 (0.40) | SOS1AAK1NCEH1NPC1RECQL | |
| SCHEMBL15755068 | 0.79 | AAK1 (0.41) | SOS1LMNAPOLBAAK1NCEH1 | |
| SCHEMBL18719604 | 0.79 | AAK1 (0.39) | SOS1PTGDR2LMNAAAK1NCEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3998263-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Jemincare Pharmaceuticals Co., Ltd. (CN) | 2022-05-18 | — | — | EP | disclosed |