Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.36 |
| ▸ | HTR3B | O95264 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pseudotropine SCHEMBL6944859 | 1.00 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL38978 | 1.00 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL21563309 | 1.00 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL100196 | 1.00 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL31078606 | 1.00 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL64824 | 1.00 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL745726 | 1.00 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL228981 | 0.97 | LMNA (0.94) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL7296801 | 0.97 | LMNA (0.94) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL7296808 | 0.97 | LMNA (0.94) | LMNACYP2C9CHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215085-B1 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-09-07 | — | — | EP | disclosed |