Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.94 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.94 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.35 |
| ▸ | HTR3B | O95264 | 2/20 | 0.35 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pseudotropine SCHEMBL7296801 | 1.00 | LMNA (0.94) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL64824 | 0.97 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL21563309 | 0.97 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL100196 | 0.97 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL31078606 | 0.97 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL2442824 | 0.97 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL745726 | 0.97 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL6944859 | 0.97 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL38978 | 0.97 | LMNA (1.00) | LMNACYP2C9CHRM3CHRM2CHRM1 | |
| Pseudotropine SCHEMBL228981 | 0.94 | LMNA (0.94) | LMNACYP2C9CHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102367251-B | More stable tropisetron compound and pharmaceutical composition thereof | JINFENG HE | 2012-11-07 | — | — | CN | disclosed |
| CN-102584815-A | Method for preparing tropisetron hydrochloride on large scale | HUNAN KAMP INST FOR MEDICAL RES | 2012-07-18 | — | — | CN | disclosed |
| CN-102367251-A | More stable tropisetron compound and pharmaceutical composition thereof | JINFENG HE | 2012-03-07 | — | — | CN | disclosed |
| CN-100503601-C | Process of preparing troipisetron | BEIJING CHENGYU CHEMICAL INDUS (CN) | 2009-06-24 | — | — | CN | disclosed |
| CN-101033225-A | Process of preparing troipisetron | BEIJING CHENGYU CHEMICAL INDUS (CN) | 2007-09-12 | — | — | CN | disclosed |
| EP-0560604-B1 | Cinnoline-3-carboxylic acid derivatives as 5-HT3 antagonists | MITSUBISHI CHEM CORP (JP) | 1997-01-29 | — | — | EP | disclosed |
| US-5556851-A | TREATMENT OF NAUSEA OR EMESIS FROM ANTICANCER DRUGS OR X-RAY TREATMENT | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-09-17 | — | — | US | disclosed |
| US-5391549-A | Antagonistifc activity against serotonin 5HT3 receptors | MITSUBISHI KASEI CORPORATION (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0560604-A1 | Cinnoline-3-carboxylic acid derivatives as 5-HT3 antagonists | Mitsubishi Chemical Corporation (JP) | 1993-09-15 | — | — | EP | disclosed |