SCHEMBL24428616

SCHEMBL24428616

CCOC(=O)C(CO)CCN

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CPB2 Q96IY4 2/20 0.51
CYP1A2 P05177 1/20 0.41
ALOX15 P16050 1/20 0.39
ALDH1A1 P00352 3/20 0.37
MEN1 O00255 1/20 0.37
NPC1 O15118 1/20 0.37
KMT2A Q03164 1/20 0.37
LMNA P02545 1/20 0.36
HSD17B10 Q99714 1/20 0.36
GABRR1 P24046 2/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
MGAM O43451 1/20 0.34
GAA P10253 1/20 0.34
SI P14410 1/20 0.34
MGAM2 Q2M2H8 1/20 0.34
SOAT1 P35610 1/20 0.34
CAD P27708 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5201455 0.88 CPB2 (0.62) CPB2CYP1A2ALOX15ALDH1A1MEN1
SCHEMBL27960938 0.85 CPB2 (0.53) CPB2CYP1A2ALOX15ALDH1A1MEN1
SCHEMBL15592501 0.85 CPB2 (0.53) CPB2CYP1A2ALOX15ALDH1A1MEN1
Hydrochloric Acid SCHEMBL28260810 0.83 CPB2 (0.51) CPB2CYP1A2ALOX15ALDH1A1MEN1
SCHEMBL22623276 0.83 CPB2 (0.51) CPB2CYP1A2ALOX15ALDH1A1MEN1
SCHEMBL10838604 0.83 CPB2 (0.46) CPB2CYP1A2ALOX15ALDH1A1MEN1
SCHEMBL27813936 0.83 HDAC1 (0.46) CPB2ALOX15ALDH1A1MEN1NPC1
SCHEMBL1405922 0.83 CPB2 (0.42) CPB2ALOX15ALDH1A1MEN1NPC1
SCHEMBL3316813 0.82 ALDH1A1 (0.48) CPB2ALOX15ALDH1A1MEN1NPC1
SCHEMBL15899439 0.80 CPB2 (0.49) CPB2CYP1A2ALOX15ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3256446-B1 (2S,4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-4-(ETHOXYOXALYLAMINO)-2-HYDROXYMETHYL-2-METHYLPENTANOIC ACID AS NEPRILYSIN INHIBITOR THERAVANCE BIOPHARMA R&D IP LLC (US) 2022-05-18 EP disclosed