Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16803633 | 0.77 | ACHE (0.42) | KDM4EALDH1A1POLBCHRM2CHRM4 | |
| SCHEMBL24428783 | 0.76 | CHRM2 (0.37) | KDM4EALDH1A1POLBCHRM2CHRM4 | |
| SCHEMBL24428838 | 0.76 | CHRM2 (0.37) | KDM4EALDH1A1POLBCHRM2CHRM4 | |
| SCHEMBL7508975 | 0.73 | LMNA (0.41) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL1290932 | 0.73 | CARM1 (0.58) | POLBACHECARM1PRMT6PRMT1 | |
| SCHEMBL2611013 | 0.72 | ACHE (0.38) | KDM4EALDH1A1POLBCHRM2CHRM4 | |
| SCHEMBL21667834 | 0.72 | ACHE (0.38) | KDM4EALDH1A1POLBCHRM2CHRM4 | |
| SCHEMBL12794000 | 0.72 | ACHE (0.38) | KDM4EALDH1A1POLBCHRM2CHRM4 | |
| Ammonia Solution, Strong SCHEMBL1492475 | 0.72 | CARM1 (0.56) | POLBACHECARM1PRMT6PRMT1 | |
| Fluoride SCHEMBL30330491 | 0.72 | CARM1 (0.56) | POLBACHECARM1PRMT6PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519393-B1 | SUBSTITUTED FUSED BI- OR TRI- HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS | EPIZYME INC (US) | 2022-05-18 | — | — | EP | disclosed |