⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1702085 | 0.97 | TSHR (0.63) | — | |
| SCHEMBL374773 | 0.97 | TSHR (0.63) | — | |
| SCHEMBL7382880 | 0.97 | TSHR (0.63) | — | |
| SCHEMBL3972155 | 0.97 | TSHR (0.63) | — | |
| SCHEMBL3980051 | 0.97 | TSHR (0.63) | — | |
| SCHEMBL1654498 | 0.97 | TSHR (0.63) | — | |
| SCHEMBL6539108 | 0.97 | TSHR (0.63) | — | |
| SCHEMBL970516 | 0.97 | TSHR (0.63) | — | |
| SCHEMBL1401237 | 0.97 | TSHR (0.63) | — | |
| SCHEMBL7292218 | 0.97 | TSHR (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230102146-A1 | MULTI-TARGET TYROSINE KINASE INHIBITOR | SHENZHEN NEPTUNUS PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (CN) | 2023-03-30 | — | — | US | claimed |
| EP-4108666-A1 | MULTI-TARGET TYROSINE KINASE INHIBITOR | Shenzhen Neptunus Pharmaceutical Research Institute Co., Ltd. (CN) | 2022-12-28 | — | — | EP | claimed |
| CN-113336768-B | Multi-target tyrosine kinase inhibitor | 深圳海王医药科技研究院有限公司 | 2022-08-19 | — | — | CN | claimed |
| CN-113336768-A | Multi-target tyrosine kinase inhibitor | 深圳海王医药科技研究院有限公司 | 2021-09-03 | — | — | CN | claimed |
| WO-2009111513-A1 | ENGINEERED CO2 FIXING MICROORGANISMS PRODUCING CARBON-BASED PRODUCTS OF INTEREST | JOULE BIOTECHNOLOGIES, INC. (US) | 2009-09-11 | — | — | WO | claimed |
| US-5674467-A | USED IN NMR DIAGNOSIS, RADIODIAGNOSIS OR RADIOTHERAPY | INSTITUT FUR DIAGNOSTIKFORSCHUNG GMBH (DE) | 1997-10-07 | — | — | US | claimed |
| EP-0333174-B1 | Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-05-08 | — | — | EP | claimed |
| US-5187156-A | D-Tryptophan- and Phenylalanine-containing tripeptides as tachykinin antagonists; asthma | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-02-16 | — | — | US | claimed |
| EP-0333174-A2 | Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-09-20 | — | — | EP | claimed |
| EP-0312157-A2 | Tetrapeptide renin inhibitors having a novel c-terminal amino acid | MERCK & CO. INC. (US) | 1989-04-19 | — | — | EP | claimed |
| US-4668781-A | Ceph-3-one compounds and process for their manufacture | CIBA-GEIGY CORPORATION (US) | 1987-05-26 | — | — | US | claimed |
| US-20230102146-A1 | MULTI-TARGET TYROSINE KINASE INHIBITOR | SHENZHEN NEPTUNUS PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (CN) | 2023-03-30 | — | — | US | disclosed |
| EP-4108666-A1 | MULTI-TARGET TYROSINE KINASE INHIBITOR | Shenzhen Neptunus Pharmaceutical Research Institute Co., Ltd. (CN) | 2022-12-28 | — | — | EP | disclosed |
| CN-113336768-B | Multi-target tyrosine kinase inhibitor | 深圳海王医药科技研究院有限公司 | 2022-08-19 | — | — | CN | disclosed |
| CN-113336768-A | Multi-target tyrosine kinase inhibitor | 深圳海王医药科技研究院有限公司 | 2021-09-03 | — | — | CN | disclosed |
| US-4152450-A | 9-Amino-dibenzopyrans | ELI LILLY AND COMPANY (US) | 1979-05-01 | — | — | US | disclosed |
| US-4008313-A | Novel corticoids | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-02-15 | — | — | US | disclosed |
| US-4000275-A | BENZIMIDAZO(2,1-B) QUINAZOLIN-12(6H)ONES | ELI LILLY AND COMPANY (US) | 1976-12-28 | — | — | US | disclosed |
| US-3987040-A | 3-SUBSTITUTED METHYL-7-ACYLAMINO-7-METHOXY-2-CEPHEM-4-CARBOXYLIC ACID AND ITS ESTERS | MERCK & CO., INC. (US) | 1976-10-19 | — | — | US | disclosed |
| US-3936478-A | Process for the preparation of desmosterol derivatives | TEIJIN LIMITED (JA) | 1976-02-03 | — | — | US | disclosed |