Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.42 |
| ▸ | FEN1 | P39748 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24429345 | 0.85 | ALDH1A1 (0.50) | CCR2ALDH1A1CYP3A4CYP2C9MAPK1 | |
| SCHEMBL1794606 | 0.84 | ALDH1A1 (0.46) | CCR2ALDH1A1CYP3A4CYP2C9MAPK1 | |
| SCHEMBL8023235 | 0.84 | MCL1 (0.51) | ALDH1A1CYP3A4CYP2C9MAPK1POLB | |
| SCHEMBL24429413 | 0.82 | CCR2 (0.59) | CCR2ALDH1A1 | |
| SCHEMBL21929678 | 0.82 | MAPT (0.41) | CCR2ALDH1A1CYP3A4CYP2C9MAPK1 | |
| SCHEMBL14930239 | 0.82 | NMT1 (0.54) | CCR2ALDH1A1CYP3A4CYP2C9MAPK1 | |
| SCHEMBL14676434 | 0.82 | KCNH2 (0.46) | CCR2ALDH1A1POLBKCNH2AHR | |
| SCHEMBL2371266 | 0.81 | CCR2 (0.53) | CCR2ALDH1A1POLBKCNH2LMNA | |
| SCHEMBL16259891 | 0.80 | CNR1 (0.43) | CCR2ALDH1A1CYP3A4CYP2C9MAPK1 | |
| SCHEMBL2929280 | 0.80 | ALDH1A1 (0.45) | CCR2ALDH1A1CYP3A4CYP2C9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220153734-A1 | Pyrazolopyridine Compounds For IRE1 Inhibition | Optikira, LLC | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153734-A1 | Pyrazolopyridine Compounds For IRE1 Inhibition | XBP1, ERN1, ERN2 | CCR2 1323/4885ALDH1A1 2438/4885CYP3A4 3675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.