Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12932769 | 0.88 | GNAI3 (0.37) | ALDH1A1 | |
| SCHEMBL15315424 | 0.88 | GNAI3 (0.37) | ALDH1A1 | |
| SCHEMBL18838953 | 0.85 | KDM4E (0.33) | PTPN11KDM4E | |
| SCHEMBL25368717 | 0.85 | KDM4E (0.33) | PTPN11KDM4E | |
| SCHEMBL12245493 | 0.80 | ADORA2A (0.33) | — | |
| SCHEMBL14737759 | 0.80 | ADORA2A (0.33) | — | |
| SCHEMBL25233513 | 0.79 | LMNA (0.35) | ALDH1A1PTPN11KDM4E | |
| Hydrochloric Acid SCHEMBL14738192 | 0.78 | ADORA2A (0.32) | — | |
| Hydrochloric Acid SCHEMBL2378908 | 0.78 | ADORA2A (0.32) | — | |
| Hydrochloric Acid SCHEMBL14738190 | 0.78 | ADORA2A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675858-B1 | IMIDAZO[1,5-A]PYRAZINE COMPOUNDS AND COMPOSITIONS FOR IRE1 INHIBITION | OPTIKIRA LLC (US) | 2023-04-26 | — | — | EP | disclosed |
| US-20220153734-A1 | Pyrazolopyridine Compounds For IRE1 Inhibition | Optikira, LLC | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153734-A1 | Pyrazolopyridine Compounds For IRE1 Inhibition | XBP1, ERN1, ERN2 | ALDH1A1 2438/4885PTPN11 3106/4885KDM4E 1043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.