SCHEMBL2443219

SCHEMBL2443219

O=C(Nc1noc2ccccc12)Oc1ccc2ccccc2c1

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 3/20 0.54
TP53 P04637 6/20 0.54
SMN1; SMN2 Q16637 6/20 0.54
MAPT P10636 2/20 0.54
HIF1A Q16665 2/20 0.52
KDM4E B2RXH2 2/20 0.50
FAAH O00519 3/20 0.49
ALOX15 P16050 1/20 0.45
TSHR P16473 1/20 0.45
KCNJ6 P48051 1/20 0.45
KCNJ3 P48549 1/20 0.45
EPHX1 P07099 1/20 0.43
MAOB P27338 1/20 0.41
IDO1 P14902 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2438083 0.87 KDM4E (0.51) EPHX2TP53SMN1; SMN2MAPTHIF1A
SCHEMBL2439294 0.87 TP53 (0.46) EPHX2TP53SMN1; SMN2MAPTHIF1A
SCHEMBL896377 0.85 TP53 (0.56) EPHX2TP53SMN1; SMN2MAPTHIF1A
SCHEMBL2442149 0.82 KDM4E (0.45) TP53SMN1; SMN2MAPTHIF1AKDM4E
SCHEMBL2437975 0.79 KDM4E (0.43) EPHX2TP53SMN1; SMN2MAPTHIF1A
SCHEMBL2442920 0.76 SMN1; SMN2 (0.50) EPHX2TP53SMN1; SMN2MAPTHIF1A
SCHEMBL2449178 0.76 MEN1 (0.39) EPHX2TP53SMN1; SMN2MAPTHIF1A
SCHEMBL2445067 0.75 TP53 (0.50) EPHX2TP53SMN1; SMN2MAPTHIF1A
SCHEMBL12636152 0.73 TP53 (0.55) EPHX2TP53SMN1; SMN2MAPTHIF1A
SCHEMBL7089986 0.73 SMN1; SMN2 (0.63) EPHX2TP53SMN1; SMN2MAPTHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893589-B1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS GRUENENTHAL GMBH (DE) 2011-09-14 EP claimed
EP-1893589-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2008-03-05 EP claimed
WO-2006131296-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2006-12-14 WO claimed
EP-1893589-B1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS GRUENENTHAL GMBH (DE) 2011-09-14 EP disclosed
EP-1893589-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2008-03-05 EP disclosed
WO-2006131296-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2006-12-14 WO disclosed