Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.46 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21240884 | 0.82 | MAPT (0.46) | TP53SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL25678133 | 0.82 | CA12 (0.45) | TP53SMN1; SMN2MAPT | |
| SCHEMBL30682021 | 0.81 | MAP4K4 (0.41) | TP53SMN1; SMN2MAPTEPHX2NPSR1 | |
| SCHEMBL2145260 | 0.81 | ALDH1A1 (0.42) | TP53SMN1; SMN2MAPTTSHRNPC1 | |
| SCHEMBL3309178 | 0.81 | CA12 (0.42) | TP53SMN1; SMN2MAPTNPC1RAB9A | |
| SCHEMBL2438375 | 0.81 | SMN1; SMN2 (0.57) | TP53SMN1; SMN2MAPTKCNA5ALOX15 | |
| SCHEMBL17202831 | 0.80 | TP53 (0.42) | TP53SMN1; SMN2MAPTMEN1NPC1 | |
| SCHEMBL31377141 | 0.80 | TP53 (0.42) | TP53SMN1; SMN2MAPTMEN1NPC1 | |
| SCHEMBL22424061 | 0.80 | CA12 (0.49) | TP53SMN1; SMN2MAPTEPHX2 | |
| SCHEMBL31377136 | 0.79 | TP53 (0.44) | TP53SMN1; SMN2MAPTALOX15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112158-A1 | BENZISOXAZOLE ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS | BOLIN DAVID ROBERT | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112158-A1 | BENZISOXAZOLE ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS | GYS2, GYS1, PYGL | TP53 4709/4885SMN1; SMN2 1624/4885MAPT 2723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.