Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.62 |
| ▸ | RAB9A | P51151 | 11/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GCK | P35557 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24434682 | 0.87 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL24435306 | 0.87 | POLB (0.45) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL24434537 | 0.86 | SMN1; SMN2 (0.60) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL24435058 | 0.86 | CSNK2A2 (0.45) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL24435120 | 0.85 | AOC3 (0.45) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL24434977 | 0.84 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL24936699 | 0.84 | POLB (0.42) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL24434684 | 0.84 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL24435244 | 0.84 | POLB (0.42) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL24434817 | 0.84 | SCD (0.47) | NPC1RAB9ASMN1; SMN2HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3930849-B1 | THIAZOLE DERIVATIVES AS PROTEIN SECRETION INHIBITORS | KEZAR LIFE SCIENCES (US) | 2025-02-19 | — | — | EP | disclosed |
| US-20220153732-A1 | PROTEIN SECRETION INHIBITORS | ENODIA THERAPEUTICS SAS (FR) | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153732-A1 | PROTEIN SECRETION INHIBITORS | SEC61B, SEC61A1, SEC61G | NPC1 407/4885RAB9A 222/4885SMN1; SMN2 4057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.