Sugi Predict

Sugi Predict / Compounds / SCHEMBL24437148

SCHEMBL24437148

SCHEMBL24437148

CCOC(=O)/C=C/c1ccc2c(c1)CCC2NS(=O)(=O)c1ccc(C)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4A P27815 2/20 0.43
▸ PDE4B Q07343 2/20 0.43
▸ PDE4C Q08493 2/20 0.43
▸ PDE4D Q08499 2/20 0.43
▸ TTR P02766 1/20 0.43
▸ DPP4 P27487 1/20 0.43
▸ CYP3A4 P08684 1/20 0.42
▸ ALDH1A1 P00352 2/20 0.41
▸ TP53 P04637 1/20 0.41
▸ HPGD P15428 1/20 0.41
▸ KCNA5 P22460 1/20 0.41
▸ CA12 O43570 2/20 0.40
▸ CA1 P00915 2/20 0.40
▸ CA2 P00918 2/20 0.40
▸ CA7 P43166 2/20 0.40
▸ CA9 Q16790 2/20 0.40
▸ CA14 Q9ULX7 2/20 0.40
▸ MAOB P27338 1/20 0.40
▸ STS P08842 2/20 0.40
▸ POLB P06746 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24437165 0.92 PDE4A (0.46) PDE4APDE4BPDE4CPDE4DTTR
SCHEMBL29652350 0.92 PDE4A (0.46) PDE4APDE4BPDE4CPDE4DTTR
SCHEMBL24437149 0.87 PDE4A (0.44) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL29652264 0.86 TTR (0.40) PDE4APDE4BPDE4CPDE4DTTR
SCHEMBL24437089 0.86 TTR (0.40) PDE4APDE4BPDE4CPDE4DTTR
SCHEMBL22517016 0.85 HDAC1 (0.55) PDE4APDE4BPDE4CPDE4DKCNA5
SCHEMBL24437231 0.81 CA12 (0.41) PDE4APDE4BPDE4CPDE4DALDH1A1
SCHEMBL24437122 0.78 THRB (0.56) PDE4APDE4BPDE4CPDE4DKCNA5
SCHEMBL24437147 0.78 HDAC1 (0.40) PDE4APDE4BPDE4CPDE4DCYP3A4
SCHEMBL22516613 0.77 HDAC1 (0.57) PDE4APDE4BPDE4CPDE4DHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12162820-B2 Peripheral alkyl and alkenyl chains extended benzene derivatives and pharmaceutical composition including the same TAIWANJ PHARMACEUTICALS CO., LTD. (TW) 2024-12-10 — — US disclosed
CN-113660932-B Phenyl derivatives having pendant alkyl and alkenyl extensions and pharmaceutical compositions comprising the same 景凯生物科技股份有限公司 2024-07-12 — — CN disclosed
US-20220153687-A1 PERIPHERAL ALKYL AND ALKENYL CHAINS EXTENDED BENZENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME TAIWANJ PHARMACEUTICALS CO., LTD. (TW) 2022-05-19 — — US disclosed
US-20220153687-A1 PERIPHERAL ALKYL AND ALKENYL CHAINS EXTENDED BENZENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME TAIWANJ PHARMACEUTICALS CO., LTD. (TW) 2022-05-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153687-A1 PERIPHERAL ALKYL AND ALKENYL CHAINS EXTENDED BENZENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AADAC, ENPP2, ATXN10 PDE4A 2690/4885PDE4B 2584/4885PDE4C 2815/4885
US-12162820-B2 Peripheral alkyl and alkenyl chains extended benzene derivatives and pharmaceutical composition including the same AADAC, ENPP2, ATXN10 PDE4A 2690/4885PDE4B 2584/4885PDE4C 2815/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.