Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24437167 | 0.89 | NPC1 (0.42) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL24437269 | 0.86 | HIF1A (0.42) | RAB9ANPC1SMN1; SMN2TSHRHIF1A | |
| SCHEMBL24437201 | 0.78 | STIM1 (0.47) | RAB9ANPC1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL24437381 | 0.77 | KDM1A (0.43) | ALDH1A1MAPTCRHR1ABCB11PDE4A | |
| SCHEMBL24437152 | 0.76 | NPC1 (0.44) | RAB9ANPC1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL24437207 | 0.73 | CRACR2A (0.45) | RAB9ANPC1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL17438083 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1POLBCRHR1CYP1A2 | |
| SCHEMBL2827007 | 0.71 | POLB (0.37) | SMN1; SMN2ALDH1A1POLBCRHR1 | |
| SCHEMBL17065278 | 0.71 | KMT2A (0.40) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17437913 | 0.71 | KMT2A (0.59) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220153735-A1 | Orai Channel Inhibitors | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153735-A1 | Orai Channel Inhibitors | ORAI2, ORAI1, ORAI3 | RAB9A 1863/4885NPC1 408/4885SMN1; SMN2 2776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.