ORAI3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Diphenyl Borinic Acid (SCHEMBL40601)	1.00	6/20
SCHEMBL1138231	0.70	6/20
SCHEMBL1003006	1.00	5/20
SCHEMBL1138482	0.80	5/20
SCHEMBL974659	0.52	5/20
Toluene (SCHEMBL735933)	0.41	5/20
SCHEMBL691860	0.50	4/20
SCHEMBL1138283	0.46	4/20
SCHEMBL435243	1.00	3/20
SCHEMBL1138738	0.65	3/20
SCHEMBL1848691	0.63	3/20
SCHEMBL1138541	0.57	3/20
SCHEMBL500599	0.55	3/20
SCHEMBL125450	0.53	3/20
SCHEMBL2218862	0.53	3/20
SCHEMBL263598	0.52	3/20
SCHEMBL263612	0.52	3/20
SCHEMBL1138563	0.52	3/20
SCHEMBL56106	0.50	3/20
SCHEMBL150115	0.50	3/20

Clinical trials — most relevant to ORAI3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility?	PHASE2/PHASE3	UNKNOWN
Role of Intralipid in Management of Organophosphorus Poisoning	PHASE2/PHASE3	WITHDRAWN
The Re-Prosper HF Study	PHASE2/PHASE3	COMPLETED
VITAL Rhythm Study	PHASE3	ACTIVE_NOT_RECRUITING
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators.	PHASE2	NOT_YET_RECRUITING
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction	PHASE2	ACTIVE_NOT_RECRUITING
Calcium Channel Blockade in Primary Aldosteronism	PHASE2	COMPLETED
Lovaza's Effect on the Activation of Platelets	PHASE2	COMPLETED
Treatment of Chronic Itch in Atopic Dermatitis With Opioid Antagonist Naltrexone	PHASE2	WITHDRAWN
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC	PHASE1	COMPLETED
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases	PHASE1	COMPLETED
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis	nan	UNKNOWN
Na+ Channel mRNA Regulation in Heart Failure	nan	COMPLETED
Study of STIM1 Membrane Expression	nan	RECRUITING
Comparison of Two Types of Calcium (Ca²⁺) Ionophore Treatments for Oocyte Activation in Cases of Suboptimal Fertilization Potential	nan	NOT_YET_RECRUITING
Multicenter Study of Patients With SHANK3 Mutations: Identification of Genes Modificators in Phelan-McDermid Syndrome (EUQ13)	nan	NOT_YET_RECRUITING
Effect of a Proposed Cav1.3 Inhibitor in Primary Aldosteronism	nan	COMPLETED
Genetic Determinants of Sudden Cardiac Death	nan	COMPLETED
The Incidence of Hypocalcemia in Pregnant Women at Siriraj Hospital	nan	UNKNOWN
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)	nan	COMPLETED
Calcium Handling and Epicardial Ablation	nan	COMPLETED
MRI-phenotyping of Patients With Pathogenic Anoctamin 5 Variants	nan	RECRUITING
How Secreted-embryo-derived Trypsin Initiates, Maintains and Terminates Ca2+ Signals in Uterine Epithelial Cells	nan	COMPLETED
Assessing Bone Calcium Content in Children With Kidney Disease Treated With Two Different Medicines	nan	UNKNOWN
Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders	nan	UNKNOWN
Evaluation of A Clinical Diagnostic Test for CRDS	nan	RECRUITING
Early Detection of Cardiomyopathy by Speckle Echo, High Sensitive Troponin and Cardiac Ryanodine Receptors	nan	UNKNOWN
Personalized Risk Prediction of Sudden Cardiac Death	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ORAI3 binder may also engage these)

Protein	Name	Similarity
Q6P8G8	—	1.000	Q6P8G8 →
Q6AXR8	—	0.999	Q6AXR8 →
ORAI1	Calcium release-activated calcium channel protein 1	0.984	landscape →
ORAI2	Protein orai-2 (CAP-binding protein complex-i	0.984	landscape →
Q8BH10	—	0.981	Q8BH10 →
Q8BWG9	—	0.979	Q8BWG9 →
Q5M848	—	0.979	Q5M848 →
Q5ZLW2	—	0.976	Q5ZLW2 →
Q5GH76	—	0.970	Q5GH76 →
Q6NZI6	—	0.969	Q6NZI6 →
Q5EAU0	—	0.968	Q5EAU0 →
Q5GH67	—	0.968	Q5GH67 →
Q49LS4	—	0.967	Q49LS4 →
Q80ZU9	—	0.966	Q80ZU9 →
Q5GH72	—	0.964	Q5GH72 →
Q5GH73	—	0.964	Q5GH73 →
Q6UXU4	—	0.964	Q6UXU4 →
Q17QQ5	—	0.963	Q17QQ5 →
Q49LS8	—	0.963	Q49LS8 →
Q4ZIN3	—	0.963	Q4ZIN3 →
Q5GH56	—	0.963	Q5GH56 →
D3Z291	—	0.962	D3Z291 →
Q8CB19	—	0.962	Q8CB19 →
A4D1U4	—	0.961	A4D1U4 →
Q8C3F2	—	0.961	Q8C3F2 →
Q17RQ9	—	0.961	Q17RQ9 →
Q5GH64	—	0.960	Q5GH64 →
P97698	—	0.960	P97698 →
Q8CIV2	—	0.960	Q8CIV2 →
A0JPH4	—	0.960	A0JPH4 →