Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 3/20 | 0.47 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.47 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24437210 | 0.89 | STIM1 (0.58) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL24437207 | 0.85 | CRACR2A (0.45) | STIM1ORAI1SMN1; SMN2LMNATSHR | |
| SCHEMBL24437265 | 0.78 | RAB9A (0.39) | SMN1; SMN2TSHRNPC1RAB9AALDH1A1 | |
| SCHEMBL24437383 | 0.75 | NPSR1 (0.42) | SMN1; SMN2LMNATSHRHTTNPSR1 | |
| SCHEMBL24437269 | 0.74 | HIF1A (0.42) | SMN1; SMN2TSHRNPC1RAB9AKMT2A | |
| SCHEMBL760185 | 0.74 | STIM1 (0.62) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL755366 | 0.73 | STIM1 (0.52) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL30096622 | 0.73 | STIM1 (0.52) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL758440 | 0.71 | SMN1; SMN2 (0.49) | STIM1ORAI1ORAI3SMN1; SMN2LMNA | |
| SCHEMBL757562 | 0.70 | STIM1 (0.67) | STIM1ORAI1ORAI3SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220153735-A1 | Orai Channel Inhibitors | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153735-A1 | Orai Channel Inhibitors | ORAI2, ORAI1, ORAI3 | STIM1 4/4885ORAI1 2/4885ORAI3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.