Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24437207 | 0.86 | CRACR2A (0.45) | NPSR1KDM4CSMN1; SMN2LMNATSHR | |
| SCHEMBL24437152 | 0.78 | NPC1 (0.44) | KDM4CGSK3ASMN1; SMN2TSHROPRM1 | |
| SCHEMBL24437379 | 0.78 | KDM4C (0.40) | KDM4CGSK3ALMNAOPRM1OPRD1 | |
| SCHEMBL24437201 | 0.75 | STIM1 (0.47) | NPSR1SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL758185 | 0.75 | STIM1 (0.49) | NPSR1SMN1; SMN2LMNATSHRHTT | |
| Hydrochloric Acid SCHEMBL756068 | 0.75 | STIM1 (0.48) | NPSR1SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL758607 | 0.72 | STIM1 (0.65) | NPSR1SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL757810 | 0.72 | NPSR1 (0.51) | NPSR1KDM4CSMN1; SMN2LMNATSHR | |
| SCHEMBL759772 | 0.72 | STIM1 (0.52) | NPSR1SMN1; SMN2LMNATSHRHTT | |
| SCHEMBL705896 | 0.72 | STIM1 (0.52) | NPSR1SMN1; SMN2LMNATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220153735-A1 | Orai Channel Inhibitors | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153735-A1 | Orai Channel Inhibitors | ORAI2, ORAI1, ORAI3 | NPSR1 1530/4885KDM4C 3959/4885GSK3A 3008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.