SCHEMBL2443752

SCHEMBL2443752

CN(C)c1ccc(N(C)C)c(Cl)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 7/20 0.46
KMT2A Q03164 1/20 0.46
MAPT P10636 6/20 0.38
KDM4E B2RXH2 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
NPC1 O15118 1/20 0.37
LMNA P02545 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
RAB9A P51151 1/20 0.37
CHEK1 O14757 1/20 0.37
NEK2 P51955 1/20 0.37
LIMK1 P53667 1/20 0.37
DYRK1A Q13627 1/20 0.37
CLK4 Q9HAZ1 1/20 0.37
ALDH1A1 P00352 5/20 0.37
TSHR P16473 4/20 0.37
ALOX15 P16050 1/20 0.37
HSD17B10 Q99714 1/20 0.37
EP300 Q09472 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8927868 0.89 CYP3A4 (0.40) GAAKMT2AMAPTKDM4ESMN1; SMN2
SCHEMBL3841879 0.84 CYP3A4 (0.48) GAAKMT2AMAPTSMN1; SMN2NPC1
SCHEMBL3786708 0.81 GAA (0.52) GAAKMT2AMAPTKDM4ESMN1; SMN2
SCHEMBL30058968 0.76 GAA (0.32) GAAKMT2AFABP4
SCHEMBL19786 0.75 MAPT (0.46) GAAMAPTKDM4ESMN1; SMN2NPC1
SCHEMBL30560002 0.74 GAA (0.32) GAAKMT2A
SCHEMBL6790445 0.74 GAA (0.42) GAAKMT2AMAPTCHEK1NEK2
SCHEMBL23862833 0.73 NPSR1 (0.39) GAAKMT2AMAPTKDM4ESMN1; SMN2
SCHEMBL5395552 0.73 MAPT (0.44) GAAKMT2AMAPTKDM4ESMN1; SMN2
SCHEMBL3789548 0.72 CHEK1 (0.47) GAAKMT2AMAPTKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090205979-A1 Electrolyte-Containing Sheet For Use In Specific Detection Of Analyte Using Photocurrent TOTO LTD. (JP) 2009-08-20 US claimed
EP-2083264-A1 ELECTROLYTE-CONTAINING SHEET FOR USE IN SPECIFIC DETECTION OF ANALYTE USING PHOTOCURRENT, AND, EMPLOYING THE SHEET, METHOD OF DETECTION, SENSOR UNIT AND MEASURING APPARATUS TOTO LTD. (JP) 2009-07-29 EP claimed
US-20110220517-A1 METHOD FOR SPECIFICALLY DETECTING TEST SUBSTANCE USING PHOTOCURRENT, SENSOR UNIT USED THEREFOR, AND MEASURING DEVICE TOTO LTD. (JP) 2011-09-15 US disclosed
EP-2237030-A1 METHOD FOR SPECIFICALLY DETECTING TEST SUBSTANCE USING PHOTOCURRENT, SENSOR UNIT USED THEREFOR, AND MEASURING DEVICE Toto Ltd. (JP) 2010-10-06 EP disclosed
US-20090205979-A1 Electrolyte-Containing Sheet For Use In Specific Detection Of Analyte Using Photocurrent TOTO LTD. (JP) 2009-08-20 US disclosed
EP-2083264-A1 ELECTROLYTE-CONTAINING SHEET FOR USE IN SPECIFIC DETECTION OF ANALYTE USING PHOTOCURRENT, AND, EMPLOYING THE SHEET, METHOD OF DETECTION, SENSOR UNIT AND MEASURING APPARATUS TOTO LTD. (JP) 2009-07-29 EP disclosed