Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 7/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14979150 | 0.81 | LMNA (0.41) | LMNAKMT2AMEN1CHRM2CHRM4 | |
| SCHEMBL2386769 | 0.81 | LMNA (0.41) | LMNAKMT2AMEN1CHRM2CHRM4 | |
| SCHEMBL23499590 | 0.78 | KMT2A (0.39) | LMNAKMT2AMEN1CHRM2CHRM4 | |
| SCHEMBL13619671 | 0.78 | KMT2A (0.39) | LMNAKMT2AMEN1CHRM2CHRM4 | |
| SCHEMBL4476489 | 0.77 | LMNA (0.74) | LMNACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1599849 | 0.75 | KMT2A (0.38) | LMNAKMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL12794007 | 0.74 | CHRM1 (0.40) | KMT2AMEN1CHRM2CHRM4CHRM5 | |
| SCHEMBL2611011 | 0.74 | GAA (0.36) | LMNAKMT2AMEN1CHRM2CHRM4 | |
| SCHEMBL896956 | 0.73 | KMT2A (0.37) | LMNAKMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL2361199 | 0.73 | KMT2A (0.37) | LMNAKMT2AMEN1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215085-B1 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-09-07 | — | — | EP | disclosed |