Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 8/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2443906 | 0.81 | LMNA (0.42) | LMNAMEN1KMT2ACHRM1CHRM2 | |
| SCHEMBL13619671 | 0.81 | KMT2A (0.39) | LMNAMEN1KMT2ACHRM1CHRM2 | |
| SCHEMBL2386769 | 0.79 | LMNA (0.41) | LMNAMEN1KMT2ACHRM1CHRM2 | |
| SCHEMBL23499590 | 0.77 | KMT2A (0.39) | LMNAMEN1KMT2ACHRM1CHRM2 | |
| SCHEMBL12794007 | 0.76 | CHRM1 (0.40) | MEN1KMT2ACHRM1CHRM2CHRM4 | |
| SCHEMBL2611011 | 0.76 | GAA (0.36) | LMNAMEN1KMT2ACHRM1CHRM2 | |
| SCHEMBL13296397 | 0.76 | POLB (0.49) | LMNACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL5279915 | 0.75 | LMNA (0.74) | LMNACHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL21421564 | 0.74 | LMNA (0.44) | LMNAALDH1A1NPSR1 | |
| SCHEMBL1599849 | 0.73 | KMT2A (0.38) | LMNAMEN1KMT2ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450315-B2 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2013-05-28 | — | — | US | disclosed |