Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24439665 | 0.92 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1KDM4EMAPTCYP1A2 | |
| SCHEMBL24439546 | 0.91 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1KDM4EMAPTCYP1A2 | |
| SCHEMBL2523197 | 0.79 | CYP1A2 (0.39) | SMN1; SMN2ALDH1A1KDM4EMAPTCYP1A2 | |
| SCHEMBL24439797 | 0.77 | HTT (0.33) | SMN1; SMN2CYP1A2CYP3A4TSHRHSD17B10 | |
| SCHEMBL24439838 | 0.77 | SMN1; SMN2 (0.30) | SMN1; SMN2ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL24439543 | 0.69 | CCNT1 (0.32) | — | |
| SCHEMBL27199355 | 0.67 | CYP1A2 (0.39) | SMN1; SMN2ALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL24439556 | 0.66 | — | — | |
| SCHEMBL4204220 | 0.63 | DRD2 (0.35) | — | |
| SCHEMBL11329015 | 0.62 | PDE7A (0.45) | SMN1; SMN2ALDH1A1KDM4EMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022104206-A1 | KINASE MODULATORS AND METHODS OF USE THEREOF | NEURON23, INC. (US) | 2022-05-19 | — | — | WO | disclosed |