Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 3/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29517766 | 1.00 | ABCB11 (0.38) | ABCB11SLCO1B1KMT2AFFAR4NEK2 | |
| SCHEMBL28755991 | 0.91 | SLCO1B1 (0.46) | ABCB11SLCO1B1FFAR4NEK2LPAR1 | |
| SCHEMBL29517393 | 0.87 | SLCO1B1 (0.40) | ABCB11SLCO1B1KMT2AFFAR4NEK2 | |
| SCHEMBL24439594 | 0.87 | SLCO1B1 (0.40) | ABCB11SLCO1B1KMT2AFFAR4NEK2 | |
| SCHEMBL24440689 | 0.86 | LPAR1 (0.41) | ABCB11SLCO1B1KMT2ALPAR1ALDH1A1 | |
| SCHEMBL24439775 | 0.84 | FFAR4 (0.34) | ABCB11SLCO1B1FFAR4NEK2EGFR | |
| SCHEMBL29602253 | 0.84 | FFAR4 (0.34) | ABCB11SLCO1B1FFAR4NEK2EGFR | |
| SCHEMBL24441487 | 0.84 | ABCB11 (0.37) | ABCB11SLCO1B1FFAR4 | |
| SCHEMBL29576270 | 0.84 | ABCB11 (0.37) | ABCB11SLCO1B1FFAR4 | |
| SCHEMBL24439357 | 0.83 | KMT2A (0.35) | ABCB11SLCO1B1KMT2ALPAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022100625-A1 | NITROGEN-SUBSTITUTED AMINOCARBONATE THIOPHENE COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-05-19 | — | — | WO | disclosed |
| WO-2022100624-A1 | OXY-SUBSTITUTED AMINOCARBONATE THIOPHENE-BASED COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-05-19 | — | — | WO | disclosed |
| CN-114456147-A | Oxygen substituted amino carbonate thiophene compounds | 武汉人福创新药物研发中心有限公司 | 2022-05-10 | — | — | CN | disclosed |