Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20400672 | 0.85 | ACHE (0.43) | ERN1GAAALDH1A1KDM4EMAPT | |
| SCHEMBL5786402 | 0.85 | ACHE (0.43) | ERN1GAAALDH1A1KDM4EMAPT | |
| SCHEMBL4349469 | 0.79 | GAA (0.50) | PRKDCGAAALDH1A1TSHRTDP1 | |
| SCHEMBL16212392 | 0.77 | GAA (0.38) | PRKDCERN1GAAALDH1A1TSHR | |
| SCHEMBL1162537 | 0.76 | ALDH1A1 (0.46) | ERN1ALDH1A1ELANEMAPT | |
| SCHEMBL3504212 | 0.75 | GAA (0.38) | GAAAMY1AALDH1A1TSHRNPSR1 | |
| SCHEMBL16212030 | 0.75 | TSHR (0.55) | GAAALDH1A1TSHRTDP1NPSR1 | |
| SCHEMBL3875000 | 0.74 | ALDH1A1 (0.45) | PRKDCGAAALDH1A1KDM4ETDP1 | |
| SCHEMBL16415970 | 0.73 | SLC6A2 (0.43) | GAAALDH1A1TSHR | |
| SCHEMBL15713187 | 0.73 | HDAC4 (0.42) | GAAAMY1AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544679-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | Omeros Corporation (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112828-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2011-09-15 | — | — | WO | disclosed |