Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.33 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24448936 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2PKMCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL24449814 | 0.83 | POLB (0.45) | SMN1; SMN2POLB | |
| SCHEMBL15298999 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2PKMCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL24449467 | 0.80 | KMT2A (0.52) | SMN1; SMN2ALDH1A1POLBDPP4CYP2D6 | |
| SCHEMBL19249273 | 0.77 | DPP4 (0.43) | SMN1; SMN2PKMCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL25463792 | 0.77 | PKM (0.47) | SMN1; SMN2PKMCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL19229732 | 0.76 | PIK3CD (0.44) | SMN1; SMN2CYP1A2ALDH1A1 | |
| SCHEMBL12448072 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2PKMCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL20053259 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2PKMCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL24567517 | 0.75 | DPP4 (0.49) | SMN1; SMN2PKMCYP1A2CYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357208-A1 | MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS | Epizyme, Inc. (US) | 2023-11-09 | — | — | US | disclosed |
| US-11685732-B2 | MYST family histone acetyltransferase inhibitors | Epizyme, Inc. (US) | 2023-06-27 | — | — | US | disclosed |
| US-20220162197-A1 | MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS | Epizyme, Inc. | 2022-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220162197-A1 | MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS | EP300, KAT2A, KAT6A | SMN1; SMN2 3017/4885PKM 2437/4885CYP1A2 4665/4885 |
| US-20230357208-A1 | MYST FAMILY HISTONE ACETYLTRANSFERASE INHIBITORS | EP300, KAT2A, KAT6A | SMN1; SMN2 3017/4885PKM 2437/4885CYP1A2 4665/4885 |
| US-11685732-B2 | MYST family histone acetyltransferase inhibitors | EP300, KAT2A, KAT6A | SMN1; SMN2 3017/4885PKM 2437/4885CYP1A2 4665/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.