Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | CSF1R | P07333 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 4/20 | 0.45 |
| ▸ | CFTR | P13569 | 2/20 | 0.43 |
| ▸ | GOPC | Q9HD26 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22191310 | 0.86 | HTR7 (0.58) | KDM4ECSF1RHTR7GAAADRA1D | |
| SCHEMBL19447231 | 0.80 | CSF1R (0.61) | KDM4ECSF1RHTR7GAAADRA1D | |
| SCHEMBL31285576 | 0.78 | KDM4E (1.00) | KDM4EHTR7CFTRGOPCGAA | |
| SCHEMBL8877012 | 0.78 | KDM4E (1.00) | KDM4EHTR7CFTRGOPCGAA | |
| SCHEMBL1713363 | 0.77 | CSF1R (0.50) | KDM4ECSF1RHTR7GAAADRA1D | |
| SCHEMBL31285656 | 0.74 | KDM4E (0.81) | KDM4EHTR7CFTRGOPCGAA | |
| SCHEMBL10558458 | 0.74 | KDM4E (0.73) | KDM4EGAACYP3A4CYP2C19 | |
| SCHEMBL6000027 | 0.74 | KDM4E (0.73) | KDM4EHTR7CFTRGOPCPOLB | |
| SCHEMBL1558215 | 0.73 | CSF1R (0.41) | KDM4ECSF1RPOLBGAA | |
| SCHEMBL16041507 | 0.73 | KDM4E (0.51) | KDM4ELRRK2VNN1PFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220162182-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220162182-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | MAP3K20, MAP3K1, PACSIN2 | KDM4E 2309/4885CSF1R 2794/4885HTR7 1352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.