Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211306 | 0.67 | TSHR (0.39) | CYP1A2ALDH1A1L3MBTL1 | |
| Alcohol SCHEMBL28141224 | 0.67 | APAF1 (0.32) | GABRA1GABRB2ALDH1A1L3MBTL1 | |
| SCHEMBL36294 | 0.65 | GABRA1 (0.58) | TP53GABRA1GABRB2MGLLALDH1A1 | |
| SCHEMBL21316061 | 0.65 | MAPT (0.41) | CYP2A6ALDH1A1MAPT | |
| SCHEMBL29390847 | 0.65 | GABRA1 (0.58) | TP53GABRA1GABRB2MGLLALDH1A1 | |
| SCHEMBL25425763 | 0.65 | GABRA1 (0.58) | TP53GABRA1GABRB2MGLLALDH1A1 | |
| Benzene SCHEMBL3122858 | 0.63 | TP53 (0.56) | TP53GABRA1GABRB2MGLLMAPT | |
| Ammonia Solution, Strong SCHEMBL2638008 | 0.63 | GABRA1 (0.55) | TP53GABRA1GABRB2MGLLALDH1A1 | |
| SCHEMBL7542830 | 0.63 | GABRA1 (0.55) | TP53GABRA1GABRB2MGLLALDH1A1 | |
| SCHEMBL25402639 | 0.63 | GABRA1 (0.55) | TP53GABRA1GABRB2MGLLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796280-B2 | 2,3-disubstituted pyrazinesulfonamides as CRTH2 inhibitors | Merck Serono, S.A. (CH) | 2014-08-05 | — | — | US | disclosed |
| CN-101217957-B | 2, 3-substituted pyrazine sulfonamides as CRTH2 inhibitors | MERCK SERONO SA | 2012-04-04 | — | — | CN | disclosed |
| EP-1871374-B1 | 2,3 SUBSTITUTED PYRAZINE SULFONAMIDES AS INHIBITORS OF CRTH2 | MERCK SERONO SA (CH) | 2011-09-14 | — | — | EP | disclosed |
| US-20090054447-A1 | 2,3 Substituted Pyrazine Sulfonamides as Inhibitors of CRTH2 | LABORATOIRES SERONO S.A. (CH) | 2009-02-26 | — | — | US | disclosed |
| CN-101217957-A | 2,3 substituted pyrazine sulfonamides as inhibitors of CRTH2 | SERONO LAB (CH) | 2008-07-09 | — | — | CN | disclosed |
| EP-1871374-A2 | 2,3 SUBSTITUTED PYRAZINE SULFONAMIDES AS INHIBITORS OF CRTH2 | Laboratoires Serono SA (CH) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006111560-A2 | 2,3 SUBSTITUTED PYRAZINE SULFONAMIDES AS INHIBITORS OF CRTH2 | LABORATOIRES SERONO S.A. (CH) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054447-A1 | 2,3 Substituted Pyrazine Sulfonamides as Inhibitors of CRTH2 | HRH2, HRH1, HRH4 | TP53 4464/4885GABRA1 4489/4885GABRB2 3700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.