⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220552 | 0.59 | — | — | |
| SCHEMBL16473336 | 0.58 | ADRA2A (0.35) | — | |
| SCHEMBL2033144 | 0.56 | — | — | |
| SCHEMBL28958 | 0.56 | — | — | |
| SCHEMBL184454 | 0.56 | — | — | |
| SCHEMBL6161864 | 0.53 | — | — | |
| SCHEMBL974997 | 0.53 | — | — | |
| SCHEMBL451352 | 0.53 | — | — | |
| SCHEMBL6161866 | 0.53 | — | — | |
| SCHEMBL6723732 | 0.53 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796280-B2 | 2,3-disubstituted pyrazinesulfonamides as CRTH2 inhibitors | Merck Serono, S.A. (CH) | 2014-08-05 | — | — | US | disclosed |
| CN-101217957-B | 2, 3-substituted pyrazine sulfonamides as CRTH2 inhibitors | MERCK SERONO SA | 2012-04-04 | — | — | CN | disclosed |
| EP-1871374-B1 | 2,3 SUBSTITUTED PYRAZINE SULFONAMIDES AS INHIBITORS OF CRTH2 | MERCK SERONO SA (CH) | 2011-09-14 | — | — | EP | disclosed |
| US-20090054447-A1 | 2,3 Substituted Pyrazine Sulfonamides as Inhibitors of CRTH2 | LABORATOIRES SERONO S.A. (CH) | 2009-02-26 | — | — | US | disclosed |
| CN-101217957-A | 2,3 substituted pyrazine sulfonamides as inhibitors of CRTH2 | SERONO LAB (CH) | 2008-07-09 | — | — | CN | disclosed |
| EP-1871374-A2 | 2,3 SUBSTITUTED PYRAZINE SULFONAMIDES AS INHIBITORS OF CRTH2 | Laboratoires Serono SA (CH) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006111560-A2 | 2,3 SUBSTITUTED PYRAZINE SULFONAMIDES AS INHIBITORS OF CRTH2 | LABORATOIRES SERONO S.A. (CH) | 2006-10-26 | — | — | WO | disclosed |