Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27903899 | 0.99 | MAPT (0.48) | MAPTHDAC6ALDH1A1KMT2ARAB9A | |
| SCHEMBL2387706 | 0.89 | MAPT (0.49) | MAPTHDAC6ALDH1A1KMT2ARAB9A | |
| SCHEMBL27903917 | 0.79 | TRPV1 (0.46) | MAPTALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL27903900 | 0.73 | KMT2A (0.55) | MAPTALDH1A1KMT2ARAB9AKDM4E | |
| SCHEMBL26398689 | 0.73 | HDAC6 (0.71) | MAPTHDAC6ALDH1A1KMT2ARAB9A | |
| SCHEMBL27887007 | 0.71 | MAPT (0.49) | MAPTALDH1A1KMT2ARAB9AMEN1 | |
| SCHEMBL11830100 | 0.70 | MAPT (0.49) | MAPTHDAC6ALDH1A1KMT2ARAB9A | |
| SCHEMBL2951325 | 0.69 | ALDH1A1 (0.71) | MAPTHDAC6ALDH1A1KMT2ARAB9A | |
| SCHEMBL2172085 | 0.69 | MAPT (0.50) | MAPTHDAC6ALDH1A1KMT2ARAB9A | |
| SCHEMBL5742108 | 0.68 | ALDH1A1 (0.69) | MAPTHDAC6ALDH1A1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102869355-B | Pde10 inhibitors and related compositions and methods | OMEROS CORP | 2015-07-08 | — | — | CN | disclosed |
| CN-104710385-A | PDE10 inhibitors and related compositions and methods | OMEROS CORP | 2015-06-17 | — | — | CN | disclosed |
| EP-2544679-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | Omeros Corporation (US) | 2013-01-16 | — | — | EP | disclosed |
| CN-102869355-A | Pde10 inhibitors and related compositions and methods | OMEROS CORP | 2013-01-09 | — | — | CN | disclosed |
| WO-2011112828-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2011-09-15 | — | — | WO | disclosed |