Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2445118 | 0.88 | TNKS2 (0.50) | TNKS2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL2914283 | 0.82 | TNKS2 (0.86) | TNKS2PDE4DTUBB4ATUBBTUBA3C | |
| SCHEMBL2007007 | 0.82 | TNKS2 (0.68) | TNKS2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL28346720 | 0.81 | HTR2A (0.53) | TNKS2KDM4EHTR2AHTR2CHTR2B | |
| SCHEMBL17295146 | 0.80 | TNKS2 (0.60) | TNKS2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL918659 | 0.79 | HSD17B10 (0.51) | TNKS2PDE4DPOLB | |
| SCHEMBL13908971 | 0.78 | TNKS2 (0.62) | TNKS2PDE4DTUBB4ATUBBTUBA3C | |
| SCHEMBL22609994 | 0.78 | TNKS2 (0.62) | TNKS2PDE4DTUBB4ATUBBTUBA3C | |
| SCHEMBL2442396 | 0.78 | ALDH1A1 (0.50) | TNKS2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL81112 | 0.77 | KDM4E (0.63) | TNKS2TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544679-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | Omeros Corporation (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112828-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2011-09-15 | — | — | WO | disclosed |