Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.68 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.60 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.60 |
| ▸ | TUBB | P07437 | 4/20 | 0.60 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.60 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.60 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.60 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.60 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.60 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.60 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.60 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.60 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.60 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.60 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.60 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23266383 | 0.94 | TUBB1 (0.63) | TNKS2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL4740186 | 0.92 | TUBB4A (0.61) | TNKS2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL20376310 | 0.89 | TNKS2 (0.60) | TNKS2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL5833688 | 0.88 | HTR2A (0.64) | TNKS2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL7424861 | 0.87 | HTR2A (0.69) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL22609994 | 0.87 | TNKS2 (0.62) | TNKS2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL27570422 | 0.86 | TNKS2 (0.53) | TNKS2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL8772722 | 0.84 | TNKS2 (0.51) | TNKS2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL2914283 | 0.84 | TNKS2 (0.86) | TNKS2TUBB1TUBB4ATUBBTUBA3C | |
| SCHEMBL4042724 | 0.84 | TNKS2 (0.58) | TNKS2TUBB1TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240327878-A1 | PSEUDOMONAS PUTIDA STRAINS ENGINEERED FOR PRODUCTION OF MUCONIC ACID FROM P-METHOXYLATED BENZOIC ACIDS | Alliance for Energy Innovation, LLC | 2024-10-03 | — | — | US | disclosed |
| EP-3746440-B1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | UNIV TEXAS (US) | 2023-07-05 | — | — | EP | disclosed |
| EP-3746440-B1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | UNIV TEXAS (US) | 2023-07-05 | — | — | EP | disclosed |
| US-11345659-B2 | Pipecolic esters for inhibition of the proteasome | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-05-31 | — | — | US | disclosed |
| US-11345659-B2 | Pipecolic esters for inhibition of the proteasome | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-05-31 | — | — | US | disclosed |
| US-20210002220-A1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2021-01-07 | — | — | US | disclosed |
| US-20210002220-A1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY | 2021-01-07 | — | — | US | disclosed |
| EP-3746440-A1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | Board of Regents, The University of Texas System (US) | 2020-12-09 | — | — | EP | disclosed |
| EP-3007696-B1 | NOVEL ALLOSTERIC INHIBITORS OF PROTEASOME AND METHODS OF USE THEREOF | UNIV TEXAS (US) | 2019-10-16 | — | — | EP | disclosed |
| EP-3007696-B1 | NOVEL ALLOSTERIC INHIBITORS OF PROTEASOME AND METHODS OF USE THEREOF | UNIV TEXAS (US) | 2019-10-16 | — | — | EP | disclosed |
| US-5795908-A | FKBP IMMUNOPHILINS FOR ENZYME INHIBITORS | GPI NIL HOLDINGS, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| EP-0801071-A1 | LEWIS X DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-15 | — | — | EP | disclosed |
| EP-0769006-A4 | — | GUILFORD PHARM INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0769006-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1997-04-23 | — | — | EP | disclosed |
| US-5614547-A | Small molecule inhibitors of rotamase enzyme | GUILFORD PHARMACEUTICALS INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996040633-A9 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | — | 1997-02-27 | — | — | WO | disclosed |
| WO-1996040633-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5321135-A | Process for the preparation of polycyclic compounds using ferric perchlorate and acid trifluoroacidic | TSUMURA & CO. (JP) | 1994-06-14 | — | — | US | disclosed |
| EP-0594890-A1 | Polycyclic compounds, their preparation and their use as phosphodiesterases inhibitors | TSUMURA & CO. (JP) | 1994-05-04 | — | — | EP | disclosed |
| EP-0511666-A1 | Process for the preparation of polycyclic compounds | TSUMURA & CO. (JP) | 1992-11-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11345659-B2 | Pipecolic esters for inhibition of the proteasome | PSMG3, PSME3, PSMC1 | TNKS2 1320/4885TUBB1 723/4885TUBB4A 1159/4885 |
| US-20210002220-A1 | PIPECOLIC ESTERS FOR INHIBITION OF THE PROTEASOME | PSMG3, PSME3, PSMC1 | TNKS2 1320/4885TUBB1 723/4885TUBB4A 1159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.