Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29133611 | 0.81 | MIF (0.36) | ALDH1A1POLBMIFLMNATSHR | |
| SCHEMBL29272325 | 0.76 | POLB (0.38) | ALDH1A1POLBMIFLMNATSHR | |
| SCHEMBL24993950 | 0.76 | CYP2C19 (0.37) | ALDH1A1CYP3A4CYP2C19CYP2C9POLB | |
| SCHEMBL28474394 | 0.76 | GAA (0.43) | ALDH1A1POLBMIFLMNATSHR | |
| SCHEMBL30236895 | 0.75 | MIF (0.31) | POLBMIFSIGMAR1 | |
| SCHEMBL169393 | 0.74 | ALDH1A1 (0.42) | ALDH1A1CYP3A4CYP2C19CYP2C9POLB | |
| SCHEMBL22273315 | 0.73 | ALDH1A1 (0.43) | ALDH1A1CYP3A4CYP2C19CYP2C9POLB | |
| SCHEMBL31013161 | 0.73 | ALDH1A1 (0.38) | ALDH1A1CYP3A4CYP2C19CYP2C9POLB | |
| SCHEMBL31013030 | 0.73 | ALDH1A1 (0.38) | ALDH1A1CYP3A4CYP2C19CYP2C9POLB | |
| SCHEMBL7804568 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240116943-A1 | TETRAHYDROBENZOFURODIAZEPINONE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2024-04-11 | — | — | US | disclosed |
| EP-4227308-A1 | TETRAHYDROBENZOFURODIAZEPINONE COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | Japan Tobacco Inc. (JP) | 2023-08-16 | — | — | EP | disclosed |
| CN-116437927-A | Tetrahydrobenzodiazepine ketone compound and pharmaceutical application thereof | 日本烟草产业株式会社 | 2023-07-14 | — | — | CN | disclosed |
| US-11643417-B2 | Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2023-05-09 | — | — | US | disclosed |
| US-11643417-B2 | Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2023-05-09 | — | — | US | disclosed |
| US-20220162220-A1 | TETRAHYDROBENZOFURODIAZEPINONE COMPOUND AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2022-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240116943-A1 | TETRAHYDROBENZOFURODIAZEPINONE COMPOUND AND PHARMACEUTICAL USE THEREOF | PIM1, PIM2, PIM3 | ALDH1A1 76/4885CYP3A4 92/4885CYP2C19 17/4885 |
| US-11643417-B2 | Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof | PIM1, PIM2, PIM3 | ALDH1A1 76/4885CYP3A4 92/4885CYP2C19 17/4885 |
| US-20220162220-A1 | TETRAHYDROBENZOFURODIAZEPINONE COMPOUND AND PHARMACEUTICAL USE THEREOF | PIM1, PIM2, PIM3 | ALDH1A1 76/4885CYP3A4 92/4885CYP2C19 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.