Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 4/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 3/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24455258 | 0.81 | NOS2 (0.40) | NOS2PDE3BPDE3ANOS3CYP3A4 | |
| SCHEMBL9019314 | 0.79 | NOS2 (0.50) | NOS2PDE3BPDE3ANOS3CCR1 | |
| SCHEMBL21567686 | 0.72 | NOS2 (0.56) | NOS2PDE3BPDE3ANOS3CCR1 | |
| SCHEMBL19006356 | 0.72 | NOS2 (0.52) | NOS2PDE3BPDE3ANOS3CCR1 | |
| SCHEMBL12051931 | 0.69 | RXFP1 (0.36) | NOS2NOS3CCR1CCR5CCR8 | |
| SCHEMBL21567478 | 0.69 | CCR1 (0.35) | NOS2PDE3BPDE3ANOS3CCR1 | |
| SCHEMBL12051932 | 0.69 | MAPT (0.36) | NOS2NOS3CCR1CCR5CCR8 | |
| SCHEMBL12528205 | 0.69 | NOS2 (0.54) | NOS2NOS3CCR1CCR5CCR8 | |
| SCHEMBL24455253 | 0.69 | NOS2 (0.33) | NOS2NOS3 | |
| SCHEMBL23987750 | 0.68 | NOS2 (0.61) | NOS2PDE3BPDE3ANOS3CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109242-A1 | PROCESS FOR PREPARING 7-CHLORO-6-FLUORO-1-(2-ISOPROPYL-4-METHYLPYRIDIN-3- YL)PYRIDOF[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE | AMGEN INC. (US) | 2022-05-27 | — | — | WO | disclosed |