Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.39 |
| ▸ | PDE4A | P27815 | 5/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24458063 | 0.82 | KDM4E (0.36) | SSTR4KDM4EHRH1HRH4HRH3 | |
| SCHEMBL27102681 | 0.79 | IRAK4 (0.38) | IRAK4CHRM3PDE4APDE4BPDE4C | |
| SCHEMBL24457915 | 0.77 | PIK3CA (0.46) | IRAK4SSTR4CYP3A4ALOX15HSD17B10 | |
| SCHEMBL12240425 | 0.74 | KDM4E (0.40) | SSTR4TDP1KDM4EHRH1HRH4 | |
| SCHEMBL15658853 | 0.71 | MAPK1 (0.50) | IRAK4PDE10ALRRK2BRD4ATAD2 | |
| SCHEMBL16877078 | 0.71 | KDM4E (0.45) | SSTR4TDP1KDM4EHRH1HRH4 | |
| SCHEMBL20135638 | 0.70 | BRD4 (0.50) | CYP3A4HSD17B10CYP1A2CYP2D6BRD4 | |
| SCHEMBL22877217 | 0.69 | GABBR2 (0.53) | IRAK4 | |
| SCHEMBL16877079 | 0.68 | PDGFRB (0.44) | SSTR4KDM4E | |
| SCHEMBL25932818 | 0.68 | MAPK1 (0.50) | IRAK4PDE10ALRRK2BRD4ATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |