Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 3/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.31 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24458076 | 0.82 | IRAK4 (0.40) | KDM4ESSTR4HRH4HRH3HRH1 | |
| SCHEMBL12240425 | 0.80 | KDM4E (0.40) | KDM4ESSTR4HRH4HRH3HRH1 | |
| SCHEMBL27102683 | 0.77 | HRH4 (0.33) | KDM4EHRH4HRH3HRH1MAT2A | |
| SCHEMBL24587299 | 0.75 | LRRK2 (0.37) | KDM4EHRH4HRH3HRH1MAT2A | |
| SCHEMBL16877078 | 0.73 | KDM4E (0.45) | KDM4ESSTR4HRH4HRH3HRH1 | |
| SCHEMBL12240507 | 0.73 | PDGFRB (0.46) | KDM4ESSTR4HRH4HRH3HRH1 | |
| SCHEMBL12240471 | 0.73 | PDGFRB (0.42) | KDM4ESSTR4HRH4HRH3HRH1 | |
| SCHEMBL6984527 | 0.72 | NOS3 (0.37) | KDM4E | |
| SCHEMBL24458004 | 0.72 | CSF1R (0.33) | CSF1R | |
| SCHEMBL13199572 | 0.71 | NOS3 (0.48) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |