Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 2/20 | 0.34 |
| ▸ | EIF2S1 | P05198 | 1/20 | 0.34 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569593 | 0.85 | GAA (0.48) | GAAHDAC1HDAC6CES2CES1 | |
| SCHEMBL8566781 | 0.85 | GAA (0.44) | GAACES2CES1PARP14PLK1 | |
| SCHEMBL1005549 | 0.80 | ALDH1A1 (0.47) | GAAHDAC6PLK1ALDH1A1KDM4E | |
| SCHEMBL19121971 | 0.79 | GAA (0.40) | GAAHDAC1HDAC6CES2CES1 | |
| SCHEMBL24458101 | 0.78 | MAPT (0.46) | GAACES2ALDH1A1KDM4EMAPT | |
| SCHEMBL27303784 | 0.78 | SMN1; SMN2 (0.40) | CES2CES1ALDH1A1KDM4EHPGD | |
| SCHEMBL1977656 | 0.78 | KDM4E (0.44) | GAACES2CES1ALDH1A1KDM4E | |
| SCHEMBL11636186 | 0.77 | GAA (0.48) | GAAHDAC1HDAC6CES2CES1 | |
| SCHEMBL7980249 | 0.77 | GAA (0.48) | GAAHDAC1HDAC6CES2CES1 | |
| SCHEMBL24458105 | 0.77 | EZH2 (0.43) | GAAALDH1A1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |