Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 5/20 | 0.44 |
| ▸ | CES1 | P23141 | 5/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24458098 | 0.85 | GAA (0.44) | GAAHDAC1HDAC6CES2CES1 | |
| SCHEMBL2062639 | 0.79 | GAA (0.47) | GAAHDAC1HDAC6CES2CES1 | |
| SCHEMBL19121971 | 0.79 | GAA (0.40) | GAAHDAC1HDAC6CES2CES1 | |
| SCHEMBL5857864 | 0.78 | CES2 (0.48) | HDAC1HDAC6CES2CES1HDAC4 | |
| SCHEMBL29657075 | 0.78 | CES2 (0.48) | HDAC1HDAC6CES2CES1HDAC4 | |
| SCHEMBL16545842 | 0.78 | CES2 (0.48) | GAAHDAC1HDAC6CES2CES1 | |
| SCHEMBL24571393 | 0.78 | TAS1R3 (0.50) | HDAC1HDAC6CES2CES1HDAC4 | |
| SCHEMBL8572283 | 0.77 | GAA (0.48) | GAAHDAC1HDAC6CES2CES1 | |
| SCHEMBL8566781 | 0.77 | GAA (0.44) | GAACES2CES1ALDH1A1SMN1; SMN2 | |
| SCHEMBL18878112 | 0.77 | CES2 (0.44) | GAAHDAC1HDAC6CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |