Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL2381285 | 0.95 | ROCK2 (0.43) | ROCK2ROCK1LCKBTKPDGFRB | |
| SCHEMBL2421863 | 0.93 | ROCK2 (0.44) | ROCK2ROCK1PDGFRBLMNAKMT2A | |
| Acetic Acid SCHEMBL2380056 | 0.89 | ROCK2 (0.46) | ROCK2ROCK1LMNAKMT2AMAPT | |
| SCHEMBL2423455 | 0.85 | ROCK2 (0.43) | ROCK2PDGFRBLMNAKMT2AMAPT | |
| SCHEMBL2380030 | 0.84 | TP53 (0.46) | ROCK2ROCK1KMT2AMAPTTP53 | |
| Acetic Acid SCHEMBL2379971 | 0.81 | ROCK2 (0.45) | ROCK2ROCK1PDGFRBLMNAKMT2A | |
| SCHEMBL2381424 | 0.81 | LMNA (0.48) | ROCK2ROCK1LMNAKMT2AMAPT | |
| SCHEMBL2445968 | 0.78 | ROCK2 (0.42) | ROCK2ROCK1LCKBTKPDGFRB | |
| SCHEMBL2419457 | 0.77 | HTT (0.46) | ROCK2ROCK1LMNAKMT2ATP53 | |
| SCHEMBL2381290 | 0.76 | ROCK2 (0.42) | ROCK2ROCK1LCKBTKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366392-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-2366697-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |