Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24464193 | 0.89 | ROCK2 (0.66) | ROCK2ROCK1CCNE1CDK2 | |
| SCHEMBL21451348 | 0.89 | ROCK2 (0.67) | ROCK2ROCK1CCNE1CDK2 | |
| SCHEMBL17038115 | 0.87 | ROCK2 (0.67) | ROCK2ROCK1CCNE1CDK2 | |
| SCHEMBL24464173 | 0.83 | NPC1 (0.50) | ROCK2ROCK1 | |
| SCHEMBL24464163 | 0.82 | ROCK2 (0.53) | ROCK2ROCK1CCNE1CDK2 | |
| SCHEMBL24862335 | 0.80 | KDR (0.44) | ROCK2ROCK1 | |
| SCHEMBL24464147 | 0.79 | ROCK1 (0.57) | ROCK2ROCK1 | |
| SCHEMBL24464164 | 0.78 | ROCK2 (0.49) | ROCK2ROCK1MAP4K4 | |
| SCHEMBL24353607 | 0.78 | ROCK2 (0.67) | ROCK2ROCK1 | |
| SCHEMBL24464180 | 0.78 | ROCK2 (0.48) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903618-B1 | RHO KINASE INHIBITORS | KADMON CORP LLC (US) | 2022-06-01 | — | — | EP | disclosed |