Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.55 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | STK3 | Q13188 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.43 |
| ▸ | SLC2A3 | P11169 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24862286 | 0.91 | ROCK2 (0.67) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL24862663 | 0.91 | ROCK2 (0.64) | ROCK2ROCK1DYRK1ACLK4 | |
| SCHEMBL24464184 | 0.90 | ROCK2 (0.53) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL24862273 | 0.89 | ROCK2 (0.55) | ROCK2ROCK1DYRK1ACLK4 | |
| SCHEMBL24862384 | 0.89 | ROCK2 (0.53) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL17038101 | 0.87 | ROCK2 (0.68) | ROCK2ROCK1SLC2A1SLC2A3 | |
| SCHEMBL24862668 | 0.87 | ROCK2 (0.56) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL24353607 | 0.87 | ROCK2 (0.67) | ROCK2ROCK1SLC2A1SLC2A3 | |
| SCHEMBL24862354 | 0.86 | ROCK2 (0.69) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL24862408 | 0.86 | ROCK2 (0.58) | ROCK2ROCK1CLK2BLKCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903618-B1 | RHO KINASE INHIBITORS | KADMON CORP LLC (US) | 2022-06-01 | — | — | EP | disclosed |