Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24862273 | 0.93 | ROCK2 (0.55) | ROCK2ROCK1DYRK1APRKACAPRKCD | |
| SCHEMBL24464157 | 0.91 | ROCK2 (0.66) | ROCK2ROCK1DYRK1ACLK4 | |
| SCHEMBL24353607 | 0.87 | ROCK2 (0.67) | ROCK2ROCK1 | |
| SCHEMBL17038101 | 0.86 | ROCK2 (0.68) | ROCK2ROCK1 | |
| SCHEMBL19592087 | 0.85 | ROCK2 (0.68) | ROCK2ROCK1 | |
| SCHEMBL24862643 | 0.85 | ROCK2 (0.57) | ROCK2ROCK1CYP1A2 | |
| SCHEMBL24862317 | 0.85 | ROCK2 (0.45) | ROCK2ROCK1DYRK1APRKACAPRKCD | |
| SCHEMBL24862299 | 0.84 | ROCK2 (0.48) | ROCK2ROCK1DYRK1APRKACAPRKCD | |
| SCHEMBL24464173 | 0.83 | NPC1 (0.50) | ROCK2ROCK1CLK4MEN1LMNA | |
| SCHEMBL20661284 | 0.83 | ROCK2 (0.71) | ROCK2ROCK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4116293-A2 | RHO KINASE INHIBITORS | Kadmon Corporation, LLC (US) | 2023-01-11 | — | — | EP | disclosed |