SCHEMBL24465490

SCHEMBL24465490

COC(C(C)C(=O)NC(CN)Cc1ccc(NC=O)cc1)C1CCCN1C=O

nearest known ligand 0.31

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 2/20 0.31
DPP8 Q6V1X1 2/20 0.31
FAP Q12884 1/20 0.31
DPP9 Q86TI2 1/20 0.31
DPP7 Q9UHL4 1/20 0.31
CTSL P07711 1/20 0.30
CTSK P43235 1/20 0.30
MME P08473 1/20 0.30
MMEL1 Q495T6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22561398 0.82 ITGB1 (0.33)
SCHEMBL22476440 0.80 F2 (0.38) DPP4DPP8CTSLCTSKMME
SCHEMBL18683750 0.78 NPC1 (0.41)
SCHEMBL22476544 0.77 MMP1 (0.44)
SCHEMBL18752098 0.77 MME (0.44) MME
SCHEMBL19393936 0.77 ATM (0.41) DPP4
SCHEMBL21781830 0.77 PPID (0.38) DPP4DPP8MMEL1
SCHEMBL23154537 0.77 ACE (0.46) MME
SCHEMBL18688556 0.77 ACE (0.46) MME
SCHEMBL25949990 0.77 ACE (0.46) MME

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3250238-B1 ANTIBODY DRUG CONJUGATES SORRENTO THERAPEUTICS INC (US) 2022-06-01 EP disclosed