Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 0.44 |
| ▸ | MMP2 | P08253 | 9/20 | 0.44 |
| ▸ | MMP3 | P08254 | 9/20 | 0.44 |
| ▸ | MMP9 | P14780 | 6/20 | 0.44 |
| ▸ | FCER2 | P06734 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 5/20 | 0.41 |
| ▸ | MMP7 | P09237 | 5/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19443278 | 0.93 | MMP1 (0.44) | MMP1MMP2MMP3MMP9FCER2 | |
| SCHEMBL23154537 | 0.93 | ACE (0.46) | ACE | |
| SCHEMBL25949990 | 0.93 | ACE (0.46) | ACE | |
| SCHEMBL18688556 | 0.93 | ACE (0.46) | ACE | |
| SCHEMBL22476506 | 0.92 | ACE (0.41) | ACE | |
| SCHEMBL21699268 | 0.92 | CYP2C9 (0.49) | — | |
| SCHEMBL21699258 | 0.92 | CYP2C9 (0.49) | — | |
| SCHEMBL22476529 | 0.89 | L3MBTL1 (0.45) | MMP1MMP2FCER2ACE | |
| SCHEMBL18683750 | 0.89 | NPC1 (0.41) | — | |
| SCHEMBL22476441 | 0.86 | ACE (0.37) | MMP1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303366-B1 | DERIVATIVES OF DOLASTATIN 10 AND USES THEREOF | NEWBIO THERAPEUTICS INC (CN) | 2020-09-30 | — | — | EP | disclosed |